[Use of recombinant alpha2-interferon in combination with myelosan for the treatment of patients with chronic myeloid leukemia].

The authors present results of chronic myeloid leukemia (CML) treatment with recombinant and leukocytic interferon in monotherapy and in combination with myelosan. The best responses (72% of complete hematological remissions) were obtained in patients pretreated with myelosan (one course of 1-1.5 months) in combination with natural antioxidants.

[Functional activity of the nucleolar organizer in the interphase granulocytic nuclei in chronic myeloid leukemia].

Silver staining was used to investigate transcription activity of ribosomal genes of leukemia granulocytes in the interphase in 32 patients with PA-positive chronic myeloid leukemia (CML) and 26 healthy subjects. Visual calculation of nucleolar argentophilic granules (AG) and measurements of AG total area on cytoanalyzer Morphoquant were made. Introduction of a specially devised computer program and combination of silver staining with autoradiography in vitro (3H-thymidine) made it possible to quantify the activity of the ribosome genes in each phase of the mitotic cycle (G0/1, S, G2).

[The treatment of chronic myeloleukemia with recombinant alfa-2 interferon].

A trial has been conducted of recombinant alpha 2-interferon (reaferon) used in 32 patients with Ph'[correction of Rh']-positive chronic myeloid leukemia (CML). A chronic stage was in 3, transient in 3 and blast in 1 patients. 25 CML patients were newly diagnosed.

[New criteria for differential diagnosis of polycythemia vera and erythrocytosis].

"Laborskel-analyzer" (PSL-1) was used to estimate red blood cell volume for the differential diagnosis in 36 polycythemia vera, 20 erythrocytosis patients and 30 normal subjects. Erythrocyte count of polycythemia vera patients (I, IIA and IIB stages) showed a shift to the left (an increase of microcytic fractions), while erythrocyte count++ of 20 erythrocytosis patients (16 of them with a relative erythrocytosis and 4 with an absolute erythrocytosis) were close to erythrocyte count++ of normal subjects. The counting of the percent content of erythrocytic fractions of varying volumes has proved fraction 5 with the erythrocytic volume from 56 microns 3 to 62 microns 3 to have the highest information content.