Patient-reported Satisfaction and Regret Following Focal Therapy for Prostate Cancer: A Prospective Multicenter Evaluation.

Background: Several reports are available regarding the treatment decision regret of patients receiving conventional treatments for localized prostate cancer (PCa); yet data on patients undergoing focal therapy (FT) are sparse.

Objective: To evaluate the treatment decision satisfaction and regret among patients who underwent FT for PCa with high-intensity focused ultrasound (HIFU) or cryoablation (CRYO).

Design Setting And Participants: We identified consecutive patients who underwent HIFU or CRYO FT as the primary treatment for localized PCa at three US institutions.

A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer.

Metastatic castration-resistant prostate cancer (mCRPC) is an immunologically cold disease with dismal outcomes. Cryoablation destroys cancer tissue, releases tumor-associated antigens and creates a pro-inflammatory microenvironment, while dendritic cells (DCs) activate immune responses through processing of antigens. Immunotherapy combinations could enhance the anti-tumor efficacy.

The Relationship between Crawling and Emotion Discrimination in 9- to 10-Month-Old Infants.

The present study examined whether infants' crawling experience is related to their sensitivity to fearful emotional expressions. Twenty-nine 9- to 10-month-old infants were tested in a preferential looking task, in which they were presented with different pairs of animated faces on a screen displaying a 100% happy facial expression and morphed facial expressions containing varying degrees of fear and happiness. Regardless of their crawling experiences, all infants looked longer at more fearful faces.

Developmental Changes in Gaze Behavior and the Effects of Auditory Emotion Word Priming in Emotional Face Categorization.

Social interactions often require the simultaneous processing of emotions from facial expressions and speech. However, the development of the gaze behavior used for emotion recognition, and the effects of speech perception on the visual encoding of facial expressions is less understood. We therefore conducted a word-primed face categorization experiment, where participants from multiple age groups (six-year-olds, 12-year-olds, and adults) categorized target facial expressions as positive or negative after priming with valence-congruent or -incongruent auditory emotion words, or no words at all.

A Multimodal Comparison of Emotion Categorization Abilities in Children With Developmental Language Disorder.

Purpose Current research has demonstrated that behavioral, emotional, and/or social difficulties often accompany developmental language disorder (DLD). It is an open question to what degrees such difficulties arise as consequence of impaired language and communicative skills, or whether they might also be driven by deficits in verbal and nonverbal emotion processing (e.g.