AOTMiT reimbursement recommendations compared to other HTA agencies.

Our objective was to compare AOTMiT (Polish: Agencja Oceny Technologii Medycznych i Taryfikacji) recommendations to other HTA (Health Technology Assessment) agencies for newly registered drugs and new registration indications issued by the European Medicines Agency between 2014 and 2019. The study aims to assess the consistency and justifications of AOTMiT recommendations compared to that of other HTA agencies in 11 countries. A total of 2496 reimbursement recommendations published by 12 HTA agencies for 464 medicinal products and 525 indications were analyzed.

Ibuprofen use for the treatment of pediatric patients with polyuria and dysnatremia. A case series report.

Children with sellar and/or suprasellar lesions may develop central diabetes insipidus with subsequent inappropriate antidiuretic hormone secretion. An increased incidence of polyuria, natriuresis, and hyponatremia has been reported in some cases, which make up the diagnostic triad of cerebral salt wasting syndrome. Here we report the clinical course of 7 patients with a history of acute central nervous system injury and central diabetes insipidus followed by cerebral salt wasting syndrome.

Carbohydrate knowledge, beliefs, and intended practices, of endurance athletes who report exercise-associated gastrointestinal symptoms.

This study aimed to explore carbohydrate (CHO) knowledge, beliefs, and intended practices of endurance athletes who experience exercise-associated gastrointestinal symptoms (Ex-GIS) compared to those without Ex-GIS. A validated online questionnaire was completed by endurance athletes ( = 201) participating in >60 min of exercise that present with Ex-GIS ( = 137) or without ( = 64). Descriptive statistics were used for parametric and non-parametric data with appropriate significance tests.

Influence of Accidental Impurities on the Spectroscopic and Luminescent Properties of ZnWO Crystal.

Special techniques for deep purification of ZnO and WO have been developed in this work. A ZnWO single crystal has been grown by the Czochralski method using purified ZnO and WO chemicals, along with the ZnWO crystal-etalon, which has been grown at the same conditions using commercially available 5N ZnO and WO chemicals. The actual accidental impurities compositions of both the initial chemicals and the grown crystals have been measured by inductively coupled plasma mass-spectrometry.