Design, synthesis and in vitro evaluation of primaquine and diaminoquinazoline hybrid molecules against the malaria parasite.

In this study, we built on the known inhibitory potential of diaminoquinazolines (DAQs) against different stages of Plasmodium development and designed a convenient two-step synthesis to combine DAQ with the primaquine (PQ) pharmacophore. The PQ-DAQ hybrids displayed potent in vitro activities in the low nanomolar range (IC50 of 135.20-398.

Serological Weak Expression of D Antigen: A Retrospective Study of Blood Donors and Patients at a Teaching Hospital in Eastern India.

Background and objective RhD variants show altered D antigen expression, affecting their serological detection. Proper identification is crucial due to potential anti-D antibody formation. This study aimed to retrospectively analyze the frequency and characteristics of D variant cases encountered during RhD typing in both blood donors and recipients and the transfusion implications.

Alterations in structural components of extracellular polymeric substance of epilithic bacteria BC1 growing on monumental rock under thermal stress.

In this study, a comparison of biofilm formation, extracellular polymeric substances (EPS) production, protein and polysaccharides estimation, and protein profiling through SDS-PAGE, FTIR, GC-MS, ESI-MS, SEM, and AFM analysis were done for EPS from epilithic bacteria BC1 obtained from monumental rock under normal room temperature and heat stressed condition. Heat stress (60 ± 2 °C) that simulates hot monumental rock surfaces during the summer season caused  bacteria BC1 to produce more EPS (8.56 g/L), biofilm, protein and polysaccharides, extra SDS-PAGE protein bands of different molecular weight than their control counterpart.