Publications by authors named "D Justin Larkin"
Article Synopsis
- The study aimed to analyze how a surgeon's learning and experience affect the outcomes of endothelial keratoplasty (EK) procedures over time.
- It examined a large dataset of EK transplants (over 11,500) performed between 2005 and 2020, focusing on factors such as surgeon experience and the timing of new EK techniques.
- The findings showed that surgeon experience significantly impacted transplant success rates and complications, highlighting the importance of training and support systems to improve surgical outcomes over time.*
Article Synopsis
- Past and ongoing selection processes have shaped the genomes of livestock breeds, helping to identify genetic traits that are important for productivity and environmental adaptation.
- The Buryat Turano-Mongolian cattle are highlighted for their ability to thrive in cold climates and low-quality forage, while Wagyu cattle are known for their high-quality marbled meat production.
- Genetic analysis methods revealed key genes linked to cold adaptation and digestion in Buryat cattle, and growth, development, and marbling traits in Wagyu, which could aid in breeding enhanced livestock suited for climate and economic challenges.
History, status and genetic characteristics of native cattle breeds from the Republic of Kazakhstan.
Vavilovskii Zhurnal Genet Selektsii
July 2024
This work provides a comprehensive review of the history, status, and genetic characteristics of cattle breeds in Kazakhstan. The current breeding status is analysed, including information on popular breeds such as Kazakh white-headed, Auliekol, Alatau, Aulieata, and Kalmyk, their production and economic significance. An overview of genetic studies using DNA fingerprinting, microsatellites, and SNPs aimed at identifying unique characteristics, genetic diversity, and genes under selection, as well as markers of economically important and productive traits of Kazakh cattle breeds, is also provided.
View Article and Find Full Text PDFThyroid hormone (TH) plays a crucial role in regulating the functions of both bone and adipose tissue. Given that TH exerts its cholesterol-lowering effects in hepatic tissue through the TH receptor-β (TRβ), we hypothesized that TRβ agonist therapy using MGL3196 (MGL) would be effective in treating increased adiposity and bone loss in response to a 12-week high-fat diet (HFD) in adult C57BL/6J mice. Transcriptional and serum profiling revealed that HFD-induced leptin promoted weight gain in both males and females, but MGL only suppressed leptin induction and weight gain in males.
View Article and Find Full Text PDFInfluence of breed and environment on leukocyte telomere length in cattle.
Vavilovskii Zhurnal Genet Selektsii
April 2024
High milk yield is associated with reduced longevity in high-producing dairy cattle breeds. Pre-term culling leads to high replacement heifer demand and economic losses for the dairy industry. Selection for this trait is limited because of low heritability and difficulties in phenotype measurement.
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