Publications by authors named "D Juska"
Article Synopsis
- The study explores the use of chimeric peptide-amphiphiles, which are peptides linked to hydrocarbon chains, for enhancing biomaterial properties like stability and cell adhesion.
- The research highlights that modifying a specific 21-residue peptide with varying lengths of hydrocarbon chains leads to the formation of a stable alpha-helical structure, which improves with longer chains.
- A combination of specific peptide-amphiphiles and a pseudolipid was found to significantly promote endothelial cell adhesion and spreading, indicating that the arrangement of these molecules is crucial for effective cellular interactions.
The matrix metalloproteinase (MMP)/matrixin family has been implicated in both normal tissue remodeling and a variety of diseases associated with abnormal turnover of extracellular matrix components. The mechanism by which MMPs catabolize collagen (collagenolysis) is still largely unknown. Substrate flexibility, MMP active sites, and MMP exosites all contribute to collagen degradation.
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