Multimodal Fusion-Based Lightweight Model for Enhanced Generalization in Drug-Target Interaction Prediction.

Predicting drug-target interactions (DTIs) with precision is a crucial challenge in the quest for efficient and cost-effective drug discovery. Existing DTI prediction models often require significant computational resources because of the intricate and exceptionally lengthy protein target sequences. This study introduces MMF-DTI, a lightweight model that uses multimodal fusion, to improve the generalizability of DTI predictions without sacrificing computational efficiency.

Aspartate aminotransferase-to-platelet ratio index outperforms Fibrosis-4 in 2843 Korean patients with metabolic dysfunction-associated steatotic liver disease.

Aim: The definition of metabolic dysfunction-associated steatotic liver disease (MASLD) has recently been proposed. We aim to investigate the diagnostic efficacy of noninvasive fibrosis markers in predicting liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated fatty liver disease (MAFLD), and MASLD.

Methods: This retrospective study involved 2843 patients diagnosed with steatotic liver disease at six tertiary hospitals in South Korea.

Modified FIB-4 Index in Type 2 Diabetes Mellitus with Steatosis: A Non-Linear Predictive Model for Advanced Hepatic Fibrosis.

The Fibrosis-4 (FIB-4) index is widely recommended as a first-tier method for screening advanced hepatic fibrosis; however, its diagnostic performance is known to be suboptimal in patients with Type 2 diabetes mellitus (T2DM). We aim to propose a modified FIB-4, using the parameters of the existing FIB-4, tailored specifically for diabetic patients with metabolic dysfunction-associated steatotic liver disease (MASLD). A total of 1503 patients who underwent liver biopsy were divided into T2DM ( = 517) and non-T2DM ( = 986) groups.

A seventeen-year, population-based study to identify dynamic patterns of interfering neck pain and its burden in South Korea.

Aim: The aim of this study were to introduce a profile of a nationwide cohort for patients with neck pain and to identify the patterns of recurrent neck pain over time.

Methods: Health insurance data for 1,127,323 patients (43.5 ± 11.

Engineering DNA Nanocube SAM Scaffolds for FRET-Based Biosensing: Interfacial Characterization and Sensor Demonstration.

Decorating a gold surface with molecular-level control over the positioning of DNA probes was demonstrated using a self-assembled monolayer (SAM) of wireframe DNA nanocube structures. The DNA nanocubes were specifically adsorbed and oriented using thiol-modified DNA on one face of the cube. The DNA nanocube SAM had a uniform coverage over the gold single crystal bead electrode with a separation of 20-30 nm measured by AFM.