Publications by authors named "D Judith"
Human respiratory syncytial virus (RSV) is an enveloped RNA virus and the leading viral agent responsible for severe pediatric respiratory infections worldwide. Identification of cellular factors able to restrict viral infection is one of the key strategies used to design new drugs against infection. Here, we report for the first time that the cellular protein BST2/Tetherin (a widely known host antiviral molecule) behaves as a restriction factor of RSV infection.
View Article and Find Full Text PDFAbscission is the final stage of cytokinesis, which cleaves the intercellular bridge (ICB) connecting two daughter cells. Abscission requires tight control of the recruitment and polymerization of the Endosomal Protein Complex Required for Transport-III (ESCRT-III) components. We explore the role of post-translational modifications in regulating ESCRT dynamics.
View Article and Find Full Text PDFConsiderable progress has been made in understanding the molecular host-virus battlefield during SARS-CoV-2 infection. Nevertheless, the assembly and egress of newly formed virions are less understood. To identify host proteins involved in viral morphogenesis, we characterize the proteome of SARS-CoV-2 virions produced from A549-ACE2 and Calu-3 cells, isolated via ultracentrifugation on sucrose cushion or by ACE-2 affinity capture.
View Article and Find Full Text PDFArticle Synopsis
- Understanding how viruses like HIV-1 evade the body's initial defense mechanisms is essential for combating infections.
- This study reveals a new role of the protein ATG5 in helping HIV-1 use the LC3C-associated pathway to degrade BST2, a restriction factor that usually traps viruses on the cell surface.
- The research also shows that HIV-1 manipulates this process to reduce inflammation caused by the detection of viruses by BST2, aiding its survival and spread.