Publications by authors named "D Jovitha Jane"
-methyl-d-aspartate receptor (NMDAR)-dependent short- and long-term types of potentiation (STP and LTP, respectively) are frequently studied in the CA1 area of dorsal hippocampal slices (DHS). Far less is known about the NMDAR dependence of STP and LTP in ventral hippocampal slices (VHS), where both types of potentiation are smaller in magnitude than in the DHS. Here, we first briefly review our knowledge about the NMDAR dependence of STP and LTP and some other forms of synaptic plasticity.
View Article and Find Full Text PDFCage effects on synaptic plasticity and its modulation in a mouse model of fragile X syndrome.
Philos Trans R Soc Lond B Biol Sci
July 2024
Article Synopsis
- Fragile X syndrome (FXS) affects executive function and memory, and this study reviews the role of breeding strategies in understanding these impairments in a mouse model.
- The research highlights significant deficits in short-term potentiation (STP), long-term potentiation (LTP), and contextual fear conditioning (CFC) in knockout (KO) mice compared to non-littermate wild-type (WT) mice, although the expression of NMDAR subunits remained unchanged.
- Notably, the effectiveness of an NMDAR modulator (UBP714) to enhance LTP induction varied based on the breeding strategy used, indicating that these strategies may cause inconsistencies in research findings related to FXS.
Ozone therapy acts in the body inducing controlled oxidative stress, thereby improving the antioxidant, immune and circulatory responses. However, very little is known about how this therapy affects oxidative stress indicators in dogs. We aimed to assess the clinical, hematological, biochemical and oxidative stress parameters of healthy dogs subjected to ozone therapy and oxygen therapy by rectal insufflation.
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