Publications by authors named "D Jochum"
Article Synopsis
- High-grade B-cell lymphoma not otherwise specified (HGBCL, NOS) shares similarities with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL), which complicates its diagnosis and treatment.
- A study on a cohort of 55 patients revealed that about 60% of HGBCL, NOS cases don't express the BL gene signature and instead display characteristics aligned with DLBCL, while showing significant genetic diversity and changes in critical regulatory genes.
- Pediatric HGBCL, NOS cases exhibited gene expressions typical of GCB-DLBCL and also showed key mutations seen in pediatric BL; the research highlighted PIM1 mutations in adults as a potential target for new therapies.
Introduction: Balance is a multifactorial construct with high relevance in, e.g., everyday life activities.
View Article and Find Full Text PDFBackground: Acute improvement in range of motion (ROM) is a widely reported effect of stretching and foam rolling, which is commonly explained by changes in pain threshold and/or musculotendinous stiffness. Interestingly, these effects were also reported in response to various other active and passive interventions that induce responses such as enhanced muscle temperature. Therefore, we hypothesized that acute ROM enhancements could be induced by a wide variety of interventions other than stretching or foam rolling that promote an increase in muscle temperature.
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- - Peripheral T-cell lymphomas (PTCLs) are diverse cancer types linked to epigenetic changes, particularly DNA methyltransferase 3A (DNMT3A) mutations, which were investigated in various PTCL forms, including angioimmunoblastic T-cell lymphoma and subtypes like PTCL-GATA3 and PTCL-TBX21.
- - DNMT3A mutations in PTCL-TBX21 cases correlate with poorer overall survival and exhibit unique patterns of gene regulation, notably hypomethylation in genes involved in T-cell activation and function, which was confirmed through various studies, including immunohistochemistry and a murine model.
- - The research highlights that DNMT3A mutations drive a cytotoxic
Background And Objectives: For superficial surgery of anteromedial and posteromedial surfaces of the upper arm, the medial brachial cutaneous nerve (MBCN) and the intercostobrachial nerve (ICBN) must be selectively blocked, in addition to an axillary brachial plexus block. We compared efficacy of ultrasound-guided (USG) versus conventional block of the MBCN and the ICBN.
Methods: Eighty-four patients, undergoing upper limb surgery, were randomized to receive either USG (n = 42) or conventional (n = 42) block of the MBCN and the ICBN with 1% mepivacaine.