Publications by authors named "D Jiandani"
Objective: To evaluate longitudinal endothelial cell characteristics of children with posterior polymorphous corneal dystrophy (PPCD).
Methods: In this prospective case-control study, children with PPCD were followed with slit-lamp photography and non-contact specular microscopy. Patient's eyes were subdivided according to the clinical subtypes of PPCD (vesicular, band, diffuse, and unaffected) and the number of lesions present on the posterior corneal surface.
Purpose: To study the longitudinal effect of anterior chamber inflammation on the corneal endothelium in children.
Methods: In this prospective longitudinal observational study, children (aged <18 years) with anterior chamber inflammation and those at risk of developing uveitis due to juvenile idiopathic arthritis (JIA) were included. Changes in central endothelial cell density (ECD) and morphological variables were determined by non-contact specular microscopy, and their correlations with uveitis activity and surgical interventions were analysed.
Article Synopsis
- The study aimed to compare the effectiveness and safety of two medications, colesevelam and ezetimibe, for lowering LDL cholesterol in patients with type 2 diabetes who have uncontrolled blood sugar levels.
- Over 24 weeks, 200 patients were randomly assigned to receive either medication, with the goal of reaching specific LDL and HbA1c levels; results showed similar effectiveness in reaching these targets.
- Ezetimibe resulted in a greater reduction in LDL cholesterol and fewer side effects compared to colesevelam, making it a more tolerable option for patients.
Objectives: This study evaluated real-world clinical outcomes of patients with type 1 diabetes (T1D) and type 2 diabetes (T2D) initiating or transferring to insulin glargine 300 U/mL (Gla-300) vs insulin glargine 100 U/mL (Gla-100).
Methods: This is a retrospective cohort study using data from the Canadian LMC Diabetes Patient Registry. The 4 following cohorts were analyzed: 1) insulin-naïve patients with T2D who initiated Gla-300 or Gla-100, 2) patients with T2D who switched from neutral protamine Hagedorn (NPH) or detemir to Gla-300 or Gla-100, 3) patients with T2D who switched from Gla-100 to Gla-300 and 4) patients with T1D who switched from Gla-100, NPH or detemir to Gla-300.
Purpose: To assess the impact of ocular trauma associated with obstetric forceps delivery on the corneal endothelium in children.
Methods: Five patients who attended the Hospital for Sick Children, Toronto, between 2013 and 2016 with a diagnosis of unilateral obstetrical forceps-related corneal injury were included. Clinical presentation, best-corrected visual acuity, corneal endothelial cell density (ECD, cells/mm), and measures of cellular morphology were obtained.