Publications by authors named "D Jake McClure"
Objective: Chronic opioid use can lead to detrimental effects on the immune and various organ systems that put individuals prescribed chronic opioid therapy (COT) for pain and those with an opioid use disorder (OUD) at risk for severe COVID-19 disease. We assessed the association of COT and OUD with COVID-19-related hospitalization and death to inform targeted interventions to improve clinical outcomes in COVID-19 patients who use opioids.
Methods: We conducted a retrospective cohort study of adults ages ≥ 18 with laboratory-confirmed SARS-CoV-2 infection in 2020 and 2021 from three US health systems.
Purpose: Vaccine-associated enhanced disease (VAED) is a theoretical concern with new vaccines, although trials of authorized vaccines against SARS-CoV-2 have not identified markers for VAED. The purpose of this study was to detect any signals for VAED among adults vaccinated against coronavirus disease 2019 (COVID-19).
Methods: In this cross-sectional study, we assessed COVID-19 severity as a proxy for VAED among 400 adults hospitalized for COVID-19 from March through October 2021 at eight US healthcare systems.
The immune response to inactivated influenza vaccines (IIV) is influenced by multiple factors, including hemagglutinin content and egg-based manufacturing. Only two US-licensed vaccines are manufactured without egg passage: cell culture-based inactivated vaccine (ccIIV) and recombinant vaccine (RIV). We conducted a randomized open-label trial in central Wisconsin during the 2018-19 and 2019-20 seasons to compare immunogenicity of sequential vaccination.
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- COVID-19 vaccinations are effective in preventing severe illness and death but their impact on post-COVID conditions (PCC) is less understood, prompting a study to evaluate this association.
- The study analyzed electronic health records from over 161,000 vaccinated and unvaccinated COVID-19 patients from multiple healthcare systems, focusing on new diagnoses of PCC within six months after infection.
- Results showed that vaccinated individuals had a lower risk of several PCC categories, especially sensory and circulatory issues, while mental health disorders had a slightly higher risk in vaccinated individuals, indicating that vaccination may help reduce long-term COVID-19 consequences.
Article Synopsis
- The study assesses outcomes in trauma patients with blunt abdominal injuries and liver cirrhosis, comparing emergency laparotomy to nonoperative management.
- It analyzed data from 929 patients, finding that those who underwent laparotomy had significantly higher mortality, required more blood, and spent longer in the ICU.
- The conclusion suggests that nonoperative management might be a safer and more effective strategy for these patients.