Publications by authors named "D J van der Meer"
While brainstem regions are central regulators of blood pressure, the neuronal mechanisms underlying their role in hypertension remain poorly understood. Here, we investigated the structural and genetic relationships between global and regional brainstem volumes and blood pressure. We used magnetic resonance imaging data from n = 32,666 UK Biobank participants, and assessed the association of volumes of the whole brainstem and its main regions with blood pressure.
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- Subcortical brain structures play a crucial role in various developmental and psychiatric disorders, and a study analyzed brain volumes in 74,898 individuals, identifying 254 genetic loci linked to these volumes, which accounted for up to 35% of variation.
- The research included exploring gene expression in specific neural cell types, focusing on genes involved in intracellular signaling and processes related to brain aging.
- The findings suggest that certain genetic variants not only influence brain volume but also have potential causal links to conditions like Parkinson’s disease and ADHD, highlighting the genetic basis for risks associated with neuropsychiatric disorders.
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- Cognitive impairment is common in individuals with epilepsy, and this study explores the genetic links between different epilepsy subtypes and cognitive ability, revealing that genetic factors play a significant role.
- Researchers analyzed data from 269,867 individuals regarding cognitive ability and 27,559 cases of common epilepsies, using various statistical tools to identify the genetic variants involved.
- The findings indicate that cognitive ability has a much larger number of genetic variants compared to epilepsy types, and they identified 66 genetic loci shared between cognitive function and different epilepsy subtypes, suggesting important gene expressions in brain regions affected by both conditions.
Article Synopsis
- Subcortical brain structures play a crucial role in various disorders, and a study analyzed the genetic basis of brain volumes in nearly 75,000 individuals of European ancestry, revealing 254 loci linked to these volumes.
- The research identified significant gene expression in neural cells, relating to brain aging and signaling, and found that polygenic scores could predict brain volumes across different ancestries.
- The study highlights genetic connections between brain volumes and conditions like Parkinson's disease and ADHD, suggesting specific gene expression patterns could be involved in neuropsychiatric disorders.
Correction for 'Flow and clogging of capillary droplets' by Yuxuan Cheng , , 2024, https://doi.org/10.1039/D4SM00752B.
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