Arterial stiffness mediates insulin resistance-related risk of atherosclerotic cardiovascular disease: a real-life, prospective cohort study.

Background: The precise pathways connecting insulin resistance (IR) to atherosclerotic cardiovascular disease (ASCVD) remain undefined. The present study aimed to examine the mediating role of arterial stiffness in the association between IR and ASCVD, providing epidemiology insights into the potential mechanisms driving IR to incident ASCVD.

Methods: A total of 59,777 participants from the Kailuan Study Arterial Stiffness Subcohort who were free of ASCVD at baseline were enrolled in the present study.

Structural insights into glucose-6-phosphate recognition and hydrolysis by human G6PC1.

The glucose-6-phosphatase (G6Pase) is an integral membrane protein that catalyzes the hydrolysis of glucose-6-phosphate (G6P) in the endoplasmic reticulum lumen and plays a vital role in glucose homeostasis. Dysregulation or genetic mutations of G6Pase are associated with diabetes and glycogen storage disease 1a (GSD-1a). Studies have characterized the biophysical and biochemical properties of G6Pase; however, the structure and substrate recognition mechanism of G6Pase remain unclear.

Distinct Promotion of PEC Water Oxidation of TaO/α-FeO/Co-Ni PBA via Coupling Ni 3d with O 2p.

The development of robust and effective photoanodes is crucial for photoelectrochemical hydrogen production via total water splitting. Herein, the TaO/α-FeO/Co-Ni PBA (TFPB-1) photoanode was constructed by the compositing n-type TaO and n-type α-FeO followed by the deposition of p-type Co-Ni PBA. The IPCE of TFPB-1 was increased to 35.

Correction: Neuroprotective effects of fermented yak milk-derived peptide LYLKPR on HO-injured HT-22 cells.

Correction for 'Neuroprotective effects of fermented yak milk-derived peptide LYLKPR on HO-injured HT-22 cells' by Yunlong Jiang , , 2022, , 12021-12038, https://doi.org/10.1039/D2FO02131E.

Transcription coactivator YAP1 promotes CCND1/CDK6 expression, stimulating cell proliferation in cloned cattle placentas.

Somatic cell nuclear transfer (SCNT) has been successfully employed across various mammalian species, yet cloned animals consistently exhibit low pregnancy rates, primarily due to placental abnormalities such as hyperplasia and hypertrophy. This study investigated the involvement of the Hippo signaling pathway in aberrant placental development in SCNT-induced bovine pregnancies. SCNT-derived cattle exhibited placental hypertrophy, including enlarged abdominal circumference and altered placental cotyledon morphology.