Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface.

Aims: The gastrointestinal (GI) tract is composed of distinct sub-regions, which exhibit segment-specific differences in microbial colonization and (patho)physiological characteristics. Gut microbes can be collectively considered as an active endocrine organ. Microbes produce metabolites, which can be taken up by the host and can actively communicate with the immune cells in the gut lamina propria with consequences for cardiovascular health.

Enhanced biodegradation of high-density polyethylene microplastics: Study of bacterial efficiency and process parameters.

As global microplastic (MP) pollution intensifies, sustainable and effective remediation methods are gaining interest due to the growing environmental and health implications. Microorganisms are demonstrating remarkable capabilities to degrade these polymers, offering a promising solution for reducing MP contamination. The aim of this study was to utilize bacteria for the degradation of high-density polyethylene (HDPE) MPs, specifically Comamonas testosteroni NCIMB 8955, Bacillus firmus NCTC 10335 and Paenibacillus macquariensis NCTC 10419.

Senescent Syncytiotrophoblast Secretion During Early Onset Preeclampsia.

Background: Preeclampsia is a severe hypertensive disorder in pregnancy that causes preterm delivery, maternal and fetal morbidity, mortality, and life-long sequelae. Understanding the pathogenesis of preeclampsia is a critical first step toward protecting mother and child from this syndrome and increased risk of cardiovascular disease later in life. However, effective early predictive tests and therapies for preeclampsia are scarce.

Gallium oxide (Ga2O3) energy dependent scintillation response to fast neutrons and flash gamma-rays.

Gallium oxide is a newly emerged ultrawide bandgap (4.9 eV) semiconductor that is suitable as a combined electronics and radiation detection platform. We have experimentally demonstrated fast neutron and gamma-ray scintillation from Czochralski-grown β-Ga2O3 in a recent series (October 2023) of experiments at the unmoderated pulsed neutron spallation source located at the Los Alamos Neutron Science Center.

Clinical use and applications of a citrate-based antiseptic lavage for the prevention and treatment of PJI.

Total joint arthroplasties (TJA) are some of the most commonly performed surgeries in the United States with the number of TJA expected to rise significantly over the next decade as the population ages and arthritic burden worsens. However, the rise in TJA volume correlates with a heightened risk of complications, notably prosthetic joint infections (PJI), despite their low occurrence rate of less than 2%. PJI imposes a significant burden on surgery success, patient well-being, and healthcare costs, with an estimated annual expense of 1.