Publications by authors named "D J Vail"
Article Synopsis
- - The study aimed to discover how common undiagnosed malignant tumors are in healthy middle-aged to older dogs, specifically those aged 5.5 to 11.5 years.
- - Out of 902 screened dogs, 2.7% were diagnosed with cancer, while an additional 3.3% had abnormalities that could indicate malignancy, raising the total to 6.0% when including suspected cases.
- - The findings highlight that thorough physical exams, especially with aspiration cytology, are essential for effectively screening for cancer in older dogs.
Article Synopsis
- A study was conducted to evaluate the effects of receiving the inactivated influenza vaccine (IIV) and SARS-CoV-2 vaccine at the same time compared to getting them separately among healthcare workers.
- Results showed that those who received both vaccines together had a lower rise in SARS-CoV-2 antibodies 1 month after vaccination, although this difference was not significant after 6 months.
- Overall, the concomitant vaccination did not seem to significantly affect the long-term immune response, suggesting that more research is needed to clarify these findings.
MAPK has been reported as a key oncogenic pathway for canine histiocytic sarcoma, which can be pharmacologically targeted with trametinib, a small inhibitor of MEK1/2. Preliminary data showed promising antitumor activity in in vitro and in vivo models and represented a proof of concept to translate the findings from bench to bedside. In this phase I, dose escalating study using a 3 + 3 cohort design, trametinib was evaluated in 18 dogs with cancer.
View Article and Find Full Text PDFCanine malignant melanoma provides a clinically relevant, large animal parallel patient population to study the GD2-reactive hu14.18-IL-2 immunocytokine as it is similar to human melanoma and expresses GD2. The objectives of this study were to evaluate safety, radiation fractionation, and identify informative biomarkers of an in-situ tumor vaccine involving local radiation therapy plus intratumoral-immunocytokine in melanoma tumor-bearing dogs.
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