Publications by authors named "D J Tsakiris"
This paper addresses the design, development, control, and experimental evaluation of a soft robot arm whose actuation is inspired by the muscular structure of the octopus arm, one of the most agile biological manipulators. The robot arm is made of soft silicone and thus possesses enhanced compliance, which is beneficial in a variety of applications where the arm may come into contact with delicate features of its environment. The arm is composed of three elongated segments arranged in series, each one of which contains several pneumatically actuated chambers embedded in its silicone body, which may induce various types of deformations of the segment.
View Article and Find Full Text PDFParoxysmal Nocturnal Hemoglobinuria (PNH) constitutes a rare bone marrow failure syndrome characterized by hemolytic anemia, thrombotic events (TEs), and bone marrow aplasia of variable degrees. Thrombosis is one of the major clinical manifestations of the disease, affecting up to 40% of individuals with PNH. Venous thrombosis is more prevalent, affecting mainly unusual sites, such as intrabdominal and hepatic veins.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluates the diagnostic significance of two immunoassay tests for heparin-induced thrombocytopenia (HIT) using data from 1393 patients, aiming to clarify the reliability of test results across their ranges.
- Findings reveal that while both assays correlate results to HIT diagnoses, the strength of this correlation differs, with the CLIA method showing a more pronounced increase in likelihood ratios compared to the ELISA method.
- A web-based calculator is provided to help clinicians estimate the probability of HIT based on individual test results, enhancing decision-making in patient care.
Hematopoietic stem cell transplantation (HCT) represents a curative treatment option for certain malignant and nonmalignant hematological diseases. Conditioning regimens before HCT, the development of graft-versus-host disease (GVHD) in the allogeneic setting, and delayed immune reconstitution contribute to early and late complications by inducing tissue damage or humoral alterations. Hemostasis and/or the complement system are biological regulatory defense systems involving humoral and cellular reactions and are variably involved in these complications after allogeneic HCT.
View Article and Find Full Text PDFArticle Synopsis
- New analytical techniques allow for the simultaneous assessment of hundreds of proteins, helping to understand their roles in diseases like heparin-induced thrombocytopenia (HIT).
- Researchers used four panels of the Olink proximity extension assay on patients suspected of HIT to identify potential new biomarkers related to thrombus formation, inflammation, and the immune response.
- The study indicated that soluble P-selectin could serve as a significant marker for HIT, with future research planned to evaluate its diagnostic and prognostic value in patient care.