Chronic topical administration of WIN-55-212-2 maintains a reduction in IOP in a rat glaucoma model without adverse effects.

Glaucoma, one of the leading causes of blindness, is associated with high intraocular pressure (IOP) as a risk factor. The aim of this study was to examine both local and systemic effects of chronic topical administration of the synthetic CB1/CB2 agonist, WIN-55-212-2 and its potential to sustain ocular hypotension. WIN-55-212-2 (0.

The intriguing problem of varicose veins.

New methods of investigation have given a fresh understanding of varicose veins. Aspects of this are described based on findings in patients investigated by Doppler flowmetry, functional phlebography and photoplethysmography. All observations refer to the upright position where various forms of failure in pumping blood upwards against gravity may arise.

Varicocele and varicose veins compared. A basis for logical surgery.

In the past only large symptomatic varicoceles were treated surgically, but this has changed now that they are believed to be a cause for infertility. Ten patients have been studied using the Doppler flowmeter and phlebography to compare varicoceles and varicose veins in the legs and to decide whether or not the same principles apply in their surgical treatment. These studies have confirmed a similar mechanism of retrograde flow from above a pumping mechanism to below it.