CFTR inhibitors.

The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a cAMP-regulated Cl- channel whose major function is to facilitate epithelial fluid secretion. Loss-of-function mutations in CFTR cause the genetic disease cystic fibrosis. CFTR is required for transepithelial fluid transport in certain secretory diarrheas, such as cholera, and for cyst expansion in autosomal dominant polycystic kidney disease.

Otitis media and associations with overweight status in toddlers.

Introduction: Otitis media (OM) is a significant disease that affects nearly all children early in life. Recently, childhood overweight has become an epidemic. Past research has demonstrated that a history of OM is related to food preferences and overweight through proposed physiological mechanisms.

Effects of moderate dietary restriction and age on blood parameters and metabolic enzymes in Lobund-Wistar rats.

The effects of moderate dietary restriction (DR) on certain blood parameters and metabolic enzymes were studied in 80 male Lobund-Wistar rats at 6, 12, 18, 24 and 30 months of age. Two groups of rats were fed ad libitum (AL) or restricted (DR) to 12 g per day from weaning. Adult DR rats received 30% less diet per day when compared to adult rats in AL group.

Carcinoid tumors: the relationship between clinical presentation and the extent of disease.

In this study the relationship between the initial clinical presentation and the extent of tumor progression was determined in a group of 31 patients with carcinoid tumors. The proportion of patients with symptomatic tumors was similar to those patients with carcinoid tumors that were incidentally found (55% versus 45%; SE = 0.089).

Capillaria procyonis (Nematoda: Trichuroidea) eggs from the tongue of the raccoon (Procyon lotor).

During an investigation to determine the prevalence and intensity of larvae of Trichinella spiralis in raccoons (Procyon lotor), unembryonated capillariid-type eggs were found routinely in the sediment resulting from 1% pepsin-HCl acid digests of the tongue. The sediment from 36 (90%) of the 40 tongue digests examined contained these capillariid-type eggs. Mean measurements of egg width and length were 25 +/- 2 microns and 62 +/- 2 microns, respectively.