Publications by authors named "D J Siebert"
Central Skull Base Osteomyelitis in Queensland, Australia, 2010-2020.
Open Forum Infect Dis
October 2024
Article Synopsis
- - Central skull base osteomyelitis (CSBO) is a serious infection affecting the bones of the skull, primarily seen in older individuals, particularly males, with diabetes being a common risk factor.
- - A study in Queensland, Australia, covering 11 years found 22 cases, highlighting a high mortality rate of 31.8% and significant long-term health issues for nearly half of the patients.
- - The diagnosis primarily relied on superficial rather than deeper microbiological sampling, and there were limited surgical treatments, indicating a need for future research to improve diagnosis and management strategies for CSBO.
Background: 1,2-propanediol (1,2-PDO) is widely used in the cosmetic, food, and drug industries with a worldwide consumption of over 1.5 million metric tons per year. Although efforts have been made to engineer microbial hosts such as Corynebacterium glutamicum to produce 1,2-PDO from renewable resources, the performance of such strains is still improvable to be competitive with existing petrochemical production routes.
View Article and Find Full Text PDFUnlabelled: A series of substituted imidazoquinolines, a structurally related chemotype to pyrazoloquinolinones, a well-known class of GABA ligands, was prepared via two synthetic procedures and the efficiency of these procedures were compared. One method relies on classical heterocyclic synthesis, the other one aims at late-stage decoration of a truncated scaffold via direct C-H functionalization. A pharmacological evaluation disclosed that one of the synthesized derivatives showed interesting activity on a α1β3 containing receptor subtype.
View Article and Find Full Text PDFBackground: Understanding the incidence, causes, and trends of sudden cardiac death (SCD) among young competitive athletes is critical to inform preventive policies.
Methods: This study included National Collegiate Athletic Association athlete deaths during a 20-year time frame (July 1, 2002, through June 30, 2022). Athlete deaths were identified through 4 separate independent databases and search strategies (National Collegiate Athletic Association resolutions list, Parent Heart Watch database and media reports, National Center for Catastrophic Sports Injury Research database, and insurance claims).