Do You Speak English or Spanish? Language as a Predictor of Health Outcomes Among Hispanic Adolescents.

Language is our primary tool for communication and a salient component of acculturation status among Hispanic populations. Importantly, language is associated with behavioral health outcomes and can identify and confront health disparities among Hispanic adolescents. The purpose of this study was to evaluate the association between adolescent language identity and drug use and depressive symptoms and examine parent-adolescent communication and parent language identity as mediators and moderators, respectively, of this association.

30 years of history, evolution, and surgical outcomes of pancreas transplants in a single Australian national pancreatic transplant unit.

Background: The first pancreas transplant in Australia was performed at Prince Henry's Hospital in 1984 (which subsequently relocated to Monash Medical Centre in 1992) in the setting of a successful pancreas transplant reported from the University of Minnesota in 1966. This study is aimed at reviewing the evolution of surgical technique in pancreas transplants and the surgical outcomes.

Methods: All pancreas transplants were reviewed from 1992 to 2022.

Percutaneous Coronary Treatment With Bioadaptor Implant vs Drug-Eluting Stent: 2-Year Outcomes From BIOADAPTOR RCT.

Background: The sirolimus-eluting bioadaptor is a novel coronary implant that unlocks, separates, and maintains dynamic support of the vessel at the lesion site 6 months after percutaneous coronary intervention when the polymer coating covering the helical strands resorbs. This enables the bioadaptor to maintain the established flow lumen and to restore hemodynamic modulation of the artery, including cyclic pulsatility, vasomotion, and adaptive remodeling.

Objectives: The purpose of this study was to report the first randomized clinical evidence of the DynamX bioadaptor implant through 2 years compared with the Resolute Onyx contemporary drug-eluting stent.

NRF2 deficiency leads to inadequate beta cell adaptation during pregnancy and gestational diabetes.

The late stages of mammalian pregnancy are accompanied by a mild increase in insulin resistance likely due to enhanced glucose demand of the growing fetus. Therefore, as an adaptive process to maintain euglycemia during pregnancy, maternal β-cell mass expands leading to increased insulin release. Defects in functional β-cell adaptive expansion during pregnancy can lead to gestational diabetes mellitus (GDM).

A prospective randomized pilot trial comparing weekly vs. biweekly Darbepoetin administration to preterm infants.

Background: Administering darbepoetin (Darbe) to preterm infants stimulates erythropoiesis, increases red blood cell (RBC) mass, and reduces RBC transfusions. We typically administer 10 µg/kg weekly until 34 weeks corrected gestation; however, we are uncertain whether this dose could be given every other week (biweekly) with equal efficacy.

Methods: Infants ≤32 weeks were randomized to receive Darbe 10 µg/kg/dose weekly or biweekly for six weeks, tracking complete blood counts, absolute reticulocyte counts (ARC), iron status (RET-He), and RBC transfusions.