Publications by authors named "D J Schutter"
Introduction: Delirium, a clinical manifestation of acute encephalopathy, is associated with extended hospitalisation, long-term cognitive dysfunction, increased mortality and high healthcare costs. Despite intensive research, there is still no targeted treatment. Delirium is characterised by electroencephalography (EEG) slowing, increased relative delta power and decreased functional connectivity.
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- The study examined the impact of cerebellar anodal transcranial direct current stimulation (tDCS) on cognitive performance among patients suffering from cerebellar cognitive affective syndrome (CCAS), where no established treatment currently exists.
- It involved 35 participants in a randomized, double-blind, sham-controlled trial with assessments of cognitive function, ataxia severity, mood, and quality of life over several months.
- The results showed no significant improvement in cognitive performance from tDCS, but did indicate a noteworthy reduction in ataxia severity, suggesting tDCS may have potential benefits for motor-related symptoms in cerebellar disorders.
Background: Different responses in human coronary arteries (HCA) and human middle meningeal arteries (HMMA) were observed for some of the novel CGRP receptor antagonists, the gepants, for inhibiting CGRP-induced relaxation. These differences could be explained by the presence of different receptor populations in the two vascular beds. Here, we aim to elucidate which receptors are involved in the relaxation to calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and adrenomedullin 2 (AM2) in HCA and HMMA.
View Article and Find Full Text PDFRhombencephalosynapsis (RES) is a hindbrain malformation characterized by a missing cerebellar vermis with apposition or fusion of the cerebellar hemispheres. The present clinical case report provides a comprehensive, longitudinal overview of cognitive and affective manifestations in a 22-year-old patient with RES. The patient shows clinical signs of emotional reactivity and dysregulation, impulsivity, and impairments in executive functioning since early childhood.
View Article and Find Full Text PDFFunctional network characteristics in anxiety- and mania-based subgroups of bipolar I disorder.
Psychiatry Res Neuroimaging
October 2024
Background: Bipolar disorder I (BD-I) is a heterogeneous disorder with a high prevalence of comorbid anxiety. The aim of this study was to investigate whether anxiety and mania symptoms define distinct subgroups within BD-I and to explore potential differences in functional network characteristics between these subgroups.
Methods: Subgroups were identified using scores from clinical anxiety and mania scales.