Publications by authors named "D J Schust"
Article Synopsis
- A study explored the effectiveness of the oral human papillomavirus (HPV) vaccine IGMKK16E7 in treating cervical intraepithelial neoplasia, showing promising results where some patients experienced a complete histological response.
- Researchers analyzed cervix-exfoliated cell samples from 42 patients to identify biomarkers that could predict the success of the vaccine, focusing on various gene expressions related to immune response.
- The key finding was that lower levels of the biomarker CD86 correlated with a higher likelihood of achieving a complete response to the vaccine, with CD86-low patients demonstrating a significantly increased response rate compared to those with higher CD86 levels.
Obstructive sleep apnea in pregnancy: A review of the literature from the obstetrics practitioner's view and a proposed clinical approach.
Eur J Obstet Gynecol Reprod Biol
September 2024
Article Synopsis
- Obstructive sleep apnea (OSA) is common in pregnant women, particularly those who are obese, and can negatively affect both maternal and fetal health, necessitating further research.
- Current diagnostic criteria and screening tools for OSA in pregnancy are limited, hindering effective referrals for diagnosis and treatment by healthcare providers.
- The review aims to enhance screening and management strategies for OSA in pregnancy, ultimately equipping obstetric practitioners to better support and counsel their patients to reduce OSA-related risks.
Ectopic pregnancies are one of the most common causes of obstetric mortality worldwide. Interstitial ectopic pregnancies, defined as an extracavitary pregnancy within the portion of the Fallopian tube that transverses the myometrium, have reported mortality rates approximately seven times higher than all types of ectopic pregnancy combined. In contrast, intracavitary eccentric gestations, often labeled as "cornual" or "angular" pregnancies, have reportedly high rates of live birth.
View Article and Find Full Text PDFArticle Synopsis
- * This review summarizes existing research on LPD, highlights the lack of validated diagnostic criteria, and discusses the controversial role of progesterone supplementation in treating RPL.
- * There's a need for better assessment tools for LPD and further research to understand its impact on fertility and find effective treatments.
Article Synopsis
- Suppressyn is a placental protein that inhibits syncytin-1, revealing complex regulation of cell fusion in the placenta.
- The study identified a promoter and a novel enhancer for suppressyn's gene, both crucial for its tissue-specific expression.
- Regulation of suppressyn expression involves DNA methylation and hypoxia-sensitive transcription factors, which could impact normal and abnormal placental development in conditions like preeclampsia and fetal growth restriction.