Publications by authors named "D J Prior"
Background: In patients with preserved left ventricular ejection fraction (LVEF), small ventricular size has been associated with reduced functional capacity, but its impact on clinical outcomes is unclear.
Objectives: The goal of this study was to determine the relationship between small heart size and premature mortality within a large multicenter adult patient cohort with transthoracic echocardiographic examinations.
Methods: We divided 366,484 individuals with LVEF ≥50% (including a subset of 279,442 individuals with high-normal LVEF ≥60%) by sex and increasing quartiles for LV end-diastolic volume (LVEDV), LVEDV indexed to body surface area (LVEDVi), and LV end-diastolic diameter to assess associations with 5-year mortality through linkage with the National Death Index.
Article Synopsis
- * In a cohort of over 21,000 adults, the AI-AAS identified significantly more cases of severe AS than initial clinical evaluations, highlighting a gender bias in diagnosis and treatment referrals.
- * Results show that while 54.4% of undiagnosed severe AS cases were women, the AI-AAS could help ensure that more patients, particularly women, receive necessary interventions for this potentially life-threatening condition.
Article Synopsis
- Pulmonary arterial hypertension and left ventricular diastolic dysfunction are serious complications in patients with systemic sclerosis, which can lead to high morbidity and mortality rates.
- A study involving 61 systemic sclerosis patients in Australia assessed the prevalence of these conditions along with their correlation to N-terminal pro-brain natriuretic peptide levels.
- The findings revealed that 8% of patients had a high likelihood of pulmonary hypertension, and those with either pulmonary hypertension or diastolic dysfunction showed significantly elevated levels of N-terminal pro-brain natriuretic peptide compared to those without these conditions.