Establishing the volatile organic compound profile and detection capabilities of human remain detection dogs to human bones.

The detection of skeletal remains using human remain detection dogs (HRD) is often reported anecdotally by handlers to be a challenge. Limited studies have been conducted to determine the volatile organic compounds (VOCs) emitted from bones, particularly when there is limited organic matter remaining. This study aimed to determine the VOCs emitted from dry, weathered bones and examine the detection performance of HRD dogs on these bones when used as training aids.

Changing Treatment and Metastatic Disease Patterns in Patients with EGFR Mutated NSCLC: An Academic Thoracic Medical Investigator's Consortium Registry Analysis.

Introduction: Osimertinib is now a standard first-line (1L) therapy for EGFR-mutated (EGFRm) advanced NSCLC. We aimed to characterize patterns of therapy and longitudinal risk of brain and liver metastasis in a cohort of EGFRm NSCLC.

Methods: Patients with metastatic EGFRm NSCLC who received 1L systemic therapy at sites within the Academic Thoracic Medical Investigator's Consortium were included; demographic and clinical data including treatment patterns were described.

Implications of an Off-Hours Setting in Patients Undergoing Transcatheter Edge-to-Edge Repair for Mitral Regurgitation.

Background: - Little is known about mitral transcatheter edge-to-edge repair (TEER) performed outside of usual working hours. We aimed to explore the prevalence, correlates, and outcomes of mitral TEER initiated off-hours, i.e.

Behind the scenes of EQA - characteristics, capabilities, benefits and assets of external quality assessment (EQA).

External quality assessment (EQA) enhances patient safety through the evaluation of the quality of laboratory-based and point of care testing. Regulatory agencies and accreditation organizations utilize the results and the laboratory's response to them as part of assessing the laboratory's fitness to practice. In addition, where EQA samples are commutable and the assigned value has been determined using reference measurement procedures (RMPs), EQA data contributes to the verification of metrological traceability of assays as part of the post-market surveillance of diagnostic (IVD) medical devices (IVD-MDs).

Recent progress in biopolymer-based electrospun nanofibers and their potential biomedical applications: A review.

Tissue engineering offers an alternative approach to developing biological substitutes that restore, maintain, or enhance tissue functionality by integrating principles from medicine, biology, and engineering. In this context, biopolymer-based electrospun nanofibers have emerged as attractive platforms due to their superior physicochemical properties, including excellent biocompatibility, non-toxicity, and desirable biodegradability, compared to synthetic polymers. Considerable efforts have been dedicated to developing suitable substitutes for various biomedical applications, with electrospinning receiving considerable attention as a versatile technique for fabricating nanofibrous platforms.