Publications by authors named "D J Moody"
Mycobacterium tuberculosis causes human tuberculosis. As mycobacteria are protected by thick lipid cell wall, humans have developed immune responses against diverse mycobacterial lipids. Most of these immunostimulatory lipids are known as adjuvants acting through innate immune receptors, such as C-type lectin receptors.
View Article and Find Full Text PDFInfectious disease is the result of interactions between host and pathogen and can depend on genetic variations in both. We conduct a genome-to-genome study of paired human and Mycobacterium tuberculosis genomes from a cohort of 1556 tuberculosis patients in Lima, Peru. We identify an association between a human intronic variant (rs3130660, OR = 10.
View Article and Find Full Text PDFFibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Little is known about what regulates the homeostatic functions of fibroblasts. Here, we perform RNA sequencing and identify a gene expression program in healthy synovial fibroblasts characterized by enhanced fatty acid metabolism and lipid transport.
View Article and Find Full Text PDFArticle Synopsis
- Discrimination during pregnancy is common among Canadians, with about 72% of pregnant individuals reporting at least one instance in the past year, linking discrimination to mental health issues such as anxiety and depression.
- The study focused on pregnant individuals, analyzing factors like race, relationship status, socioeconomic status, and pre-existing mental health conditions to understand the effects of interpersonal discrimination.
- Open-text responses from participants identified key reasons for discrimination, highlighting issues related to gender, age, and socioeconomic factors, which further contributed to the prevalence of depression and anxiety symptoms among those affected.
Article Synopsis
- - The study investigates the feasibility of using wastewater-based epidemiology (WBE) and whole-genome sequencing (WGS) to detect and differentiate between human and avian strains of Influenza A viruses (IAVs) across Northern Ireland.
- - Between August and December 2022, wastewater samples from six treatment facilities revealed a constant presence of IAVs, with varied proportions of human and avian strains, though no strong correlation was found with clinical IAV data from the region.
- - The findings suggest that WBE can effectively monitor circulating IAV strains, offering a valuable approach for ongoing surveillance and potential prevention of influenza outbreaks through genetic analysis.