High-throughput hit identification with acoustic ejection mass spectrometry.

This mini-review provides an overview of recent developments in AEMS supporting hit identification in drug discovery, emphasizing its potential to enhance the quality and efficiency of label-free HTS. Future advancements that may further expand the role of AEMS in the drug discovery process will also be discussed.

Solar geoengineering research faces geopolitical deadlock.

The permissive "science first" approach has failed, but a nondeployment deal might yet enable responsible research.

Are Oral Somatostatin Receptor Ligands Moving Closer to Becoming a Reality?

With the current therapeutic modalities available to endocrinologists, control of GH and IGF-I is now possible in almost all patients with acromegaly with multi-modality therapy. Despite biochemical control of GH and IGF-I, patients with acromegaly continue to experience impaired quality of life. Although there are likely multiple factors contributing to this dissatisfaction with current medical therapies, in particular the widely utilised injectable long-acting somatostatin receptor ligands (iSRL), is a contributor.

Quantifying protein kinetics in vivo: Influence of precursor dynamics on product labeling.

Protein kinetics can be quantified by coupling stable isotope tracer methods with mass spectrometry readouts; however, inter-connected decision points in the experimental design affect the complexity of the workflow and impact data interpretations. For example, choosing between a single bolus (pulse-chase) or a continuous exposure protocol influences subsequent decisions regarding when to measure and how to model the temporal labeling of a target protein. Herein, we examine the merits of in vivo tracer protocols, we direct attention towards stable isotope tracer experiments that rely on administering a single bolus since these are generally more practical to use as compared to continuous administration protocols.

Community-Driven Health Promotion: Evaluation of a Rural Microgrant Program.

Introduction: Microgrants for health promotion have the potential to engage communities in designing and implementing place-based interventions to improve health and social outcomes. However, the evidence base around microgrants for health promotion is limited. This study presents the evaluation of a health service-funded microgrant program for health promotion in rural Australia.