Publications by authors named "D J Levy"
Polygenic risk scores (PRSs) depend on genetic ancestry due to differences in allele frequencies between ancestral populations. This leads to implementation challenges in diverse populations. We propose a framework to calibrate PRS based on ancestral makeup.
View Article and Find Full Text PDFSumoylation is a posttranslational modification essential for multiple cellular functions in eukaryotes. ULP-2 is a conserved SUMO protease required for embryonic development in Caenorhabditis elegans. Here, we revealed that ULP-2 controls germline development by regulating the PHD-SET domain protein, SET-26.
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- The study investigates the role of NETosis in the initiation of lupus using a mouse model.
- Mice injected with pristane showed significantly more activated neutrophils and low-density granulocytes, as well as increased release of neutrophil extracellular traps compared to the control group.
- These findings suggest that early activation of neutrophils and NETosis may contribute to the development of lupus in this model.
Alterations in Response Switching in Parkinson's Disease: New Insights Into Cueing.
J Geriatr Psychiatry Neurol
December 2024
Switching, a critical executive function, can manifest as task switching (TS) or response switching (RS). Although TS impairments in Parkinson's disease (PD) are well-studied, RS, especially in contexts requiring adaptive behavior to external or internal cues, is less explored. This study evaluated the impact of PD on RS under exogenous and endogenous cueing.
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