A prospective evaluation of central venous blood flow using Doppler ultrasound in patients with a long-term central venous catheter.

Using Doppler ultrasound, we prospectively evaluated the relationship between central venous blood flow and the development of central venous thrombosis in ten patients with a long term central line. The presence of turbulent blood flow around the catheter was followed by the development of central venous thrombosis in two patients but neither had subsequent clinical sequelae. More surprisingly, however, normal blood flow was demonstrated in eight patients, two of whom subsequently developed intravascular thrombi.

Occlusion of silastic broviac catheters as a result of twisting between the catheter and hub assembly.

Occlusion is a common cause of catheter malfunction during home parenteral nutrition (HPN). We report 5 cases of central venous catheter occlusion, encountered over a 24 month period, which were associated with twisting of the catheter at the hub assembly. One catheter was replaced before the cause of the occlusion was identified.

Plasma NE concentrations do not accurately reflect sympathetic nervous system activity in human sepsis.

Plasma norepinephrine concentrations ([NE]) when raised in patients with sepsis are thought to indicate increased activity of the sympathetic nervous system (SNS). However, increased SNS activity may occur without a concomitant rise in plasma [NE]. Measurement of NE kinetics (clearance and spillover) is a more accurate and direct assessment of SNS activity.

Thermogenic and hormonal responses to amino acid infusion in septic humans.

Metabolic effects of a commercially available amino acid infusate were investigated in five preoperative patients with abdominal sepsis and five healthy subjects. Oxygen consumption (VO2) was measured continuously during the 3-h study, and blood samples were taken regularly for hormone and metabolite analyses. During 1 h of preinfusion measurements, VO2 was 15% higher (P less than 0.

Endocarditis complicating parenteral nutrition: the value of repeated echocardiography.

Cardiac complications of parenteral nutrition are well recognized but the diagnosis of such complications may be difficult. Two-dimensional echocardiography has been shown to be of value in establishing the diagnosis of valvular vegetations and right atrial thrombus. We describe two patients who developed endocarditis while receiving parenteral nutrition via central venous catheters.