Publications by authors named "D J Lacey"

Forensic examination of digital audio, video, and images frequently requires transforming multimedia data from one format to another. The transformative activity may cause changes to the administrative elements of the file but leave the multimedia streams unchanged and intact. However, the forensic science community has a method knowledge gap in accurately determining if the multimedia streams changed or remained the same in the transformative processes.

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In this audio/video authenticity research project, 44 original MOV files were produced on an Apple iPhone 12 Pro Max mobile device, running the iOS 14.2.1 operating system, in all available video formats and at four different nominal recording lengths.

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Post-transcriptional regulation mechanisms control mRNA stability or translational efficiency via ribosomes, and recent evidence indicates that it is a major determinant of the accurate levels of cytokine mRNAs. Transcriptional regulation of has been well studied and found to be important for the rapid induction of mRNA and regulation of the acute phase of inflammation, whereas study of its post-transcriptional regulation has been largely limited to the role of the AU-rich element (ARE), and to a lesser extent, to that of the constitutive decay element (CDE). We have identified another regulatory element (NRE) in the 3' UTR of and demonstrate that ARE, CDE, and NRE cooperate to efficiently downregulate expression and prevent autoimmune inflammatory diseases.

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