Publications by authors named "D J LEAHY"
Article Synopsis
- Researchers have successfully transported key membrane proteins, including EGFR and the Insulin Receptor, into extracellular vesicles (EVs) for in-depth structural and functional analysis, showcasing the potential of EVs for studying membrane protein interactions.
- Using techniques like cryo-electron tomography, they observed that these proteins, particularly EGFR, form clusters and maintain a specific distance from the membrane, which challenges previous assumptions about protein arrangement.
- This work advances our understanding of EGFR's role in signaling and development, highlighting its implications in cancer therapies and providing a new approach for examining human membrane proteins in conditions similar to their natural environment.
Article Synopsis
- * The review analyzed 204 papers, selecting 18 that demonstrated a wide range in self-harm rates—between 1.5% and 23% among adolescents (ages 15-18), with higher incidents reported in females and often occurring at home.
- * Findings highlighted that while many youths sought help from friends or family before or after self-harm episodes, professional help was rarely pursued, underscoring the need for better psychoeducation for families and enhanced mental health services.
A vaccine is needed to combat the Chlamydia epidemic. Replication-deficient viral vectors are safe and induce antigen-specific T-cell memory. We tested the ability of intramuscular immunization with modified vaccinia Ankara (MVA) virus or chimpanzee adenovirus (ChAd) expressing chlamydial outer membrane protein (OmcB) or the secreted protein, chlamydial protease-like activating factor (CPAF), to enhance T-cell immunity and protection in mice previously infected with plasmid-deficient Chlamydia muridarum CM972 and elicit protection in naïve mice.
View Article and Find Full Text PDFChlamydia is an obligate intracellular bacterial pathogen responsible for disease and infertility across multiple species. Currently vaccines are being studied to help reduce the prevalence of this disease. The main advantage of protein subunit vaccines is their high degree of safety although this is traded off with the requirement for multiple booster doses to achieve complete protection.
View Article and Find Full Text PDFBackground: Online question banks are the most widely used education resource amongst medical students. Despite this there is an absence of literature outlining how and why they are used by students. Drawing on Deci and Ryan's self-determination theory, our study aimed to explore why and how early-stage medical students use question banks in their learning and revision strategies.
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