Basic Science and Pathogenesis.

Background: Published data have highlighted associations between Alzheimer's disease (AD) susceptibility loci and AD-related brain changes. The amyloid imaging to prevent AD (AMYPAD) consortium is a European collaboration consisting of several parent cohorts, four of which had raw genotype array data available. We sought to integrate and harmonise the genetic data, calculate AD polygenic risk scores (PRS), and investigate their association with global amyloid deposition.

New Horizons of Biomarkers in Metastatic Thyroid Cancer.

This review focuses on the latest advancements in using biomarkers to diagnose, predict outcomes, and guide the treatment of different types of thyroid cancer, such as anaplastic, papillary, medullary, and follicular thyroid carcinoma. We highlight the key role of both traditional and new biomarkers in improving the treatment of these cancers. For anaplastic thyroid cancer, biomarkers are crucial for detecting distant metastases and making treatment decisions.

Polysulfone-Based Membranes Modified with Ionic Liquids and Silica for Potential Fuel Cell Applications.

The urgent need for sustainable, low-emission energy solutions has positioned proton exchange membrane fuel cells (PEMFCs) as a promising technology in clean energy conversion. Polysulfone (PSF) membranes with incorporated ionic liquid (IL) and hydrophobic polydimethylsiloxane-functionalized silica (SiO-PDMS) were developed and characterized for their potential application in PEMFCs. Using a phase inversion method, membranes with various combinations of PSFs, SiO-PDMS, and 1-butyl-3-methylimidazolium triflate (BMI.

Mortality predictors and definition proposal for complicated coagulase-negative Staphylococcus bacteremia. A multicenter prospective cohort study.

Objective: To explore a definition for complicated coagulase-negative staphylococci bloodstream infections (CoNS BSI), and to identify predictors for mortality.

Methods: Prospective cohort study conducted from October 2016 to March 2017 in 26 Spanish hospitals. Complicated CoNS BSI criteria included lack of early catheter removal in catheter-related cases, foreign indwelling implant, persistent bacteremia, fever ≥72 hours on active therapy, metastatic infection or deep-seated focus and infective endocarditis.

Supracricoid Partial Laryngectomy Versus Radiation Therapy for cT3N0M0 Glottic SCC: Outcomes in Candidates for Total Laryngectomy Responding Well to Induction Chemotherapy.

Objective: To evaluate whether supracricoid partial laryngectomy (SCPL) may be a viable alternative to radiation therapy (RT) for patients with glottic cT3N0M0 squamous cell carcinoma (SCC) who are surgical candidates for total laryngectomy (TL) and respond well to platinum-based induction chemotherapy.

Methods: Retrospective case series review of 18 consecutive patients with cT3N0M0 glottic SCC, initially considered surgical candidates only for TL who showed a good response to platinum-based induction chemotherapy, managed at a French university teaching institution with either SCPL (n = 9) or RT (n = 9). The main endpoints were 10-year local control and laryngeal preservation.