Septoplasty retards midfacial growth in a rabbit model.

Objectives/hypothesis: Septoplasty in the prepubertal age group is a controversial operation because of concerns regarding retardation of subsequent midfacial growth. This study uses a validated rabbit snout model to determine if septoplasty results in midfacial growth retardation, and if the retardation can be averted by replacing resected cartilage with a porous polyethylene implant.

Study Design: Prospective controlled animal study.

Transforming growth factor-beta1 shows an incremental osteoinductive dose-response relationship.

Objective: To determine if there is a dose-response curve for TGF-beta1 in a rabbit calvarial defect model.

Study Design: Controlled animal study using arms of increasing concentrations of TGF-beta1 to evaluate the osteoinductive potential of each arm.

Methods: Sixteen skeletally mature New Zealand white rabbits were randomized into control and experimental arms.

TGF-beta 1 forms functionally normal bone in a segmental sheep tibial diaphyseal defect.

Objective: Transforming growth factor-beta 1 (TGF-beta 1) is a polyfunctional regulatory cytokine that has been shown to have roles in extracellular matrix interactions, soft tissue healing, and osteogenesis. This study was undertaken to determine the efficacy of TGF-beta 1 in the formation of functionally normal bone in tibial-diaphyseal defects.

Method: Seven hundred fifty micrograms of recombinant human TGF-beta 1 was added to a guanidine-extracted demineralised bone matrix (Gu-DBM) carrier and the implants were used to fill a 2.