Patients' reasons for declining a primary care trial online therapy: a mixed methods study.

Background: Integrating therapist-led sessions and Cognitive Behavioural Therapy (CBT) materials within one online platform may be effective for people with depression. A trial evaluating this mode of delivering CBT is being conducted. To maximize future trial recruitment and understand patients' views of health interventions, it is important to explore reasons for declining to participate.

The use of coaching in stroke rehabilitation: a scoping review.

Purpose: Stroke results in long-term impacts on a person's life requiring ongoing management after formal rehabilitation ends. Coaching can support people to build competencies and skills for managing health-related challenges and has the potential to support stroke survivors to continue achieving goals on their own following rehabilitation. This review sought to describe the research on coaching interventions for adults living with stroke.

Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2).

The Son of Sevenless (SOS) protein family includes two highly homologous proteins, SOS1 and SOS2, that act as guanine nucleotide exchange factors (GEFs) for RAS proteins. They catalyze the GDP-to-GTP exchange, resulting in an increase of the active GTP-bound form of RAS. Despite highly similar structures and expression patterns, SOS1 is generally accepted as the dominant RAS GEF for downstream signaling in pathological states.

Maternal perinatal anxiety and infant primary care use in 1998-2016: a UK cohort study.

Background: There is some evidence that perinatal anxiety (PNA) is associated with lower rates of infant vaccinations and decreased access to preventative infant healthcare, but results across studies have not been conclusive.

Objective: To investigate the relationship between maternal PNA and infant primary care use.

Methods: Cohort study of mother-infant pairs identified between 1998 and 2016 using IQVIA Medical Research Database (IMRD).