Publications by authors named "D J Kelly"

Heart failure with preserved ejection fraction (HFpEF) is increasingly common but its pathogenesis is poorly understood. The ability to assess genetic and pharmacologic interventions is hampered by the lack of robust preclinical mouse models of HFpEF. We developed a novel "two-hit" model, which combines obesity and insulin resistance with chronic pressure overload to recapitulate clinical features of HFpEF.

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Article Synopsis
  • Patients recovering from anterior cruciate ligament reconstruction (ACLR) completed various assessments to measure strength, hop performance, and patient-reported outcomes (PROs), specifically looking at the Patient Acceptable Symptom State (PASS).
  • A total of 223 participants were evaluated for performance differences between those who did and did not meet the PASS threshold on their PROs.
  • Results indicated that patients achieving the International Knee Documentation Committee (IKDC) scores had significantly better strength and limb symmetry compared to those who did not meet this PRO threshold.
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Purpose: Lymphoma survivors who have received curative intent treatment are currently followed up at defined time points in medical and nurse-led clinics often indefinitely. The follow up protocol is often at the discretion of the treating physician. The aim of the study was to explore the clinical, biochemical and radiological presentation of patients with Diffuse Large B-cell Lymphoma (DLBCL) and Hodgkin Lymphoma (HL) treated with curative intent at the point of recurrence from first remission, and to understand if recurrence was detected at scheduled follow up.

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