Publications by authors named "D J Kase"
Although the basal ganglia (BG) plays a central role in the motor symptoms of Parkinson's disease, few studies have investigated the influence of parkinsonism on movement-related activity in the BG. Here, we studied the perimovement activity of neurons in globus pallidus internus (GPi) of non-human primates before and after the induction of parkinsonism by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neuronal responses were equally common in the parkinsonian brain as seen prior to MPTP and the distribution of different response types was largely unchanged.
View Article and Find Full Text PDF. Oscillations figure prominently as neurological disease hallmarks and neuromodulation targets. To detect oscillations in a neuron's spiking, one might attempt to seek peaks in the spike train's power spectral density (PSD) which exceed a flat baseline.
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- Fungal musculoskeletal infections can be challenging to identify due to their subtle symptoms and rarity, often overlapping with other diseases.
- These infections spread through blood, direct contact, or nearby tissue extension, with risk factors including weakened immune systems and exposure at work, and can either be isolated or part of broader systemic issues.
- Imaging plays a key role in diagnosis, revealing nonspecific signs like bone destruction and joint changes, but may also provide clues when combined with patient history and geographical context.
Article Synopsis
- * Infections such as tuberculosis are prevalent in this area, often spreading through the bloodstream, while bacterial infections are less common.
- * Although tumors are rare, they can cause severe issues like pathologic fractures or subluxation, making it crucial to accurately understand the complex anatomy and conditions of this region for effective treatment.
Objective: Oscillations figure prominently as neurological disease hallmarks and neuromodulation targets. To detect oscillations in a neuron's spiking, one might attempt to seek peaks in the spike train's power spectral density (PSD) which exceed a flat baseline. Yet for a non-oscillating neuron, the PSD is not flat: The recovery period ("RP", the post-spike drop in spike probability, starting with the refractory period) introduces global spectral distortion.
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