Publications by authors named "D J Ingle"
Phylogenetic analyses are crucial for understanding microbial evolution and infectious disease transmission. Bacterial phylogenies are often inferred from SNP alignments, with SNPs as the fundamental signal within these data. SNP alignments can be reduced to a 'strict core' by removing those sites that do not have data present in every sample.
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- Salmonella enterica serovar Panama is a significant cause of invasive non-typhoidal salmonellosis in Australia, despite being understudied, with a high incidence rate linked to international travel.
- A study analyzed genomic epidemiology and antimicrobial resistance in S. Panama isolates in Victoria from 2000 to 2021, finding that over half exhibited multi-drug resistance, and colistin resistance was identified in one isolate.
- The research also explored the growth dynamics of S. Panama in macrophages, revealing its ability to replicate more effectively compared to S. enterica serovar Typhimurium, although no specific genotype was linked to this enhanced replication.
Multidrug-resistant bacterial pathogens like vancomycin-resistant Enterococcus faecium (VREfm) are a critical threat to human health. Daptomycin is a last-resort antibiotic for VREfm infections with a novel mode of action, but for which resistance has been widely reported but is unexplained. Here we show that rifaximin, an unrelated antibiotic used prophylactically to prevent hepatic encephalopathy in patients with liver disease, causes cross-resistance to daptomycin in VREfm.
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- Cholera, caused by a Gram-negative bacterium, is a significant public health issue with millions of annual cases, primarily linked to the ongoing seventh pandemic El Tor (7PET) lineage.
- Research involving 34 bacterial isolates from travelers returning to Australia revealed that most belonged to non-7PET lineages, which still demonstrated antibiotic resistance and virulence factors.
- The study highlights how travel impacts the spread of both epidemic and non-epidemic cholera strains, emphasizing the importance of surveillance in understanding and monitoring disease diversity and transmission.
N. gonorrhoeae, which causes the sexually transmissible infection gonorrhoea, remains a significant public health threat globally, with challenges posed by increasing transmission and antimicrobial resistance (AMR). The COVID-19 pandemic introduced exceptional circumstances into communicable disease control, impacting the transmission of gonorrhoea and other infectious diseases.
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