Publications by authors named "D J Hilton"
Cullin-5 (Cul5) coordinates assembly of cullin-RING-E3 ubiquitin (Ub) ligase (CRL) complexes that include Suppressor of Cytokine Signaling (SOCS)-box-containing proteins. The SOCS-box proteins function to recruit specific substrates to the complex for ubiquitination and degradation. In hematopoiesis, SOCS-box proteins are best known for regulating the actions of cytokines that utilize the JAK-STAT signaling pathway.
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- - MYCN amplification is linked to poor outcomes in childhood neuroblastoma and the study investigates the signaling dependencies associated with it through genetic manipulation in mice.
- - A mutation in the RNF121 gene was found to result in decreased tumor formation, with RNF121 playing a crucial role in enhancing MYCN protein stability and contributing to tumor growth.
- - Elevated RNF121 levels correlate with poor prognosis in neuroblastoma and laryngeal cancer, suggesting it as a potential target for new cancer therapies.
Introduction: The cause of most CHD is unknown and considered complex, implicating genetic and environmental factors in disease causation. The Kids Heart BioBank was established in 2003 to accelerate genetic investigations into CHD.
Methods: Recruitment includes patients undergoing interventions for CHD at The Children's Hospital at Westmead.
Article Synopsis
- * This study identifies the overexpression of TAM receptors (TYRO3, AXL, MERTK) and the ligand GAS6 in tumor cells from patients, revealing new interactions between these receptors in meningioma and schwannoma tissues.
- * Researchers found that inhibiting MERTK with UNC2025 and AXL with BGB324 reduced cell growth and survival in vitro, with UNC2025 proving more effective and also depleting tumor-associated macrophages in both tumor types.