Publications by authors named "D J Haines"
Background: We sought to evaluate the anatomic and functional lesion development over time at different atrial sites immediately following delivery of pulsed field ablation (PFA).
Methods: Using a porcine model, PFA ablations were performed in the superior vena cava (SVC), right atrial lateral wall (RA), left atrial appendage (LAA), and right superior pulmonary vein (RSPV) using four different PFA profiles. Mapping was done sequentially in 5-20-min increments up to 280-min post lesion delivery for low voltage area (LVA) assessment and conduction velocity.
Adherence drives efficacy in PrEP clinical trials. We compared drug concentrations and self-reported adherence in HPTN069/ACTG5305, a double-blinded, randomized trial of the safety and tolerability of candidate PrEP regimens that included maraviroc (MVC), tenofovir (TDF), and emtricitabine (FTC). Plasma drug concentrations and self-reported adherence by computer-assisted self-interview (CASI) were assessed at study weeks 24 and 48.
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- The study examines the relationship between electrode positioning and success rates in electrical cardioversion of atrial fibrillation.
- It finds that patients requiring a single low-energy shock (100 J) for successful cardioversion had electrodes placed closer to the heart compared to those needing multiple shocks.
- The research suggests that using the xiphoid process as a landmark could help improve electrode placement and increase successful cardioversion rates.