Genomic Biomarkers Associated with Enfortumab Vedotin Outcomes for Patients with Advanced Urothelial Carcinoma: Analysis of UNITE Study Data.

Enfortumab vedotin (EV) is used as monotherapy or combined with pembrolizumab in advanced urothelial carcinoma (aUC), but biomarker data associated with EV outcomes are limited. We identified 170 patients in the UNITE study who received EV monotherapy and had molecular biomarker data available. Outcomes for groups with and without a particular biomarker were compared using logistic regression (unadjusted) for the objective response rate (ORR), and a log-rank test and Cox proportional-hazard models (CPHMs) for progression-free survival (PFS) and overall survival (OS) from EV initiation.

Quantifying the Impact of Sustained Acceleration on Critical Care Transport Medical Equipment.

Introduction: Military and commercial stakeholders are investing to explore the use of hypersonic aircraft and orbital spacecraft to transport cargo, medical supplies, passengers, and casualties. These vehicle platforms require periods of sustained acceleration, but to date, these dynamic forces have not been comprehensively considered in the environment of critical care patient movement because injured patients and advanced aeromedical evacuation (AE) equipment are rarely subjected to these conditions. While military AE equipment does undergo crash hazard acceleration testing, equipment functionality during or after sustained acceleration remains to be evaluated.

Comparison of end-to-side versus side-to-side jejunocecostomy in horses.

Objectives: To compare end-to-side (ES) and side-to-side (SS) jejunocecostomy (JC) in healthy horses.

Study Design: Experimental study in vivo.

Animals: A total of 14 healthy adult horses underwent ventral midline celiotomy, a resection, and either an ES (n = 7) or stapled SS (n = 7) JC.

Social Contributors to Differences in Math Course Attainment Among Adolescents with and without Learning Disabilities and ADHD.

Completing advanced high school math coursework relates to better adulthood outcomes. Our understanding of why youth with learning disabilities (LDs) and/or ADHD have less access to high math course attainment is limited. Using data on around 20,000 adolescents from the High School Longitudinal Study of 2009, results indicate that, regardless of disability status, structural inequities in family social position are more salient for youth's math course attainment than formal disability programming, universal supports, or structural inequities in how students are sorted across schools.

Task completion without commitment.

Unlabelled: We conduct an experiment where participants make choices between completing a task now or waiting to complete it in the future. We vary the dates when a task can be completed and the effort required at each date. We infer participants' preferences for when to complete a task and their expectations about how their future preferences will differ from their current ones.