Publications by authors named "D J Figueroa"
This study investigates gender-based differences in the gut microbiota of Simmental cattle, focusing on bacterial, archaeal, and fungal communities. Fecal samples were collected and analyzed using high-throughput sequencing, with taxonomic classification performed through the SILVA and UNITE databases. Alpha and beta diversity metrics were assessed, revealing significant differences in the diversity and composition of archaeal communities between males and females.
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- Blocking IL-13 is effective for treating atopic dermatitis (AD), and new research suggests that targeting T cell costimulatory molecules like OX40 and OX40L could also be a beneficial treatment option.
- This study investigates whether targeting CD30L might be an additional therapeutic avenue, by comparing it with existing targets like IL-13 and OX40L using single-cell RNA-seq and a murine model of AD.
- Results showed that blocking CD30L effectively reduced disease symptoms in mice, indicating that targeting the CD30-CD30L pathway could be a promising future treatment for human atopic dermatitis, similar to targeting the OX40-OX40L pathway.
Unicompartmental knee arthroplasty (UKA) faces significant challenges, including lower survival rates and higher revision rates than total knee arthroplasty (TKA). To address these issues, technological advancements like custom-made implants (CMI), patient-specific alignment (PSA), and computer-assisted systems (CAS) are being explored. These innovations aim to tailor procedures to individual joint morphology, soft tissue balance, and limb alignment, moving away from the traditional "one size fits all" approach.
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- Genome instability is linked to histone imbalances affecting DNA integrity, and histones must be properly synthesized and modified before entering the nucleus to ensure chromatin assembly.
- The histone demethylase JMJD1B is essential for supplying adequate histones H3 and H4, and its reduced levels in melanoma cells lead to cytoplasmic accumulation of histones, causing chromatin assembly defects and increased DNA damage.
- Research shows that JMJD1B knockout in melanoma cells enhances their tumorigenic properties and correlates with higher genome instability, indicating that JMJD1B plays a crucial role in maintaining genome integrity and may act as a safeguard against oncogenic mutations.