Effects of upper extremity blood flow restriction training on muscle strength and hypertrophy: a systematic review and meta-analysis.

Background: Low load resistance training with blood flow restriction (LL-BFRT) has been shown to improve muscle strength and hypertrophic function. The effect of LL-BFRT on lower extremity muscle improvement has been widely discussed. However, no studies have discussed the effect of this training method on the upper extremity muscles until now.

Analysis of Platelet Morphological Parameters as Clinical Risk Stratification in Acute Coronary Syndrome.

Background: Platelet activation plays a central role in the pathogenesis of acute coronary syndrome (ACS). Platelet morphological parameters, including MPV, PDW, and P-LCR, are emerging as biomarkers for predicting the severity of ACS and prognosis.

Aims: This study aims to assess the relationship between these parameters and coronary severity and to evaluate their predicting adverse outcomes.

Solution-phase nucleic acid reaction weaves interfacial barriers on unmodified electrodes: Just-in-time generation of sensor interface for convenient and highly sensitive bioassays.

Electrochemical bioassays that rely on sensor interfaces based on immobilized DNA probes often encounter challenges such as complex fabrication processes and limited binding efficiency. In this study, we developed a novel electrochemical bioassay that bypasses the need for probe immobilization by employing a solution-phase nucleic acid reaction to create interfacial barriers on unmodified electrodes, enabling rapid, just-in-time sensor interface formation. Specifically, a 3'-phosphorylated recognition probe was used to identify the target microRNA-21 (miR-21), followed by target recycling facilitated by duplex-specific nuclease (DSN), which resulted in extensive hydrolysis of the recognition probe into DNA fragments with 3'-hydroxyl ends.

Quantitative analysis of Fumonisin B1 using photoelectrochemical aptamer sensing strategy based on dual type II heterojunction KPWO/CdS/CoS.

Fumonisin B1 (FB1) is a highly toxic fungal toxin that poses a serious threat to human health. Accordingly, realizing highly sensitive detection of FB1 is essential to safeguard people's health. In this study, a photoelectrochemical (PEC) aptamer sensor was successfully constructed with KPWO/CdS/CoS as the substrate material and with AgBiS as the aptamer marker.

MXene-based SERS spectroscopic analysis of exosomes for lung cancer differential diagnosis with deep learning.

Lung cancer with heterogeneity has a high mortality rate due to its late-stage detection and chemotherapy resistance. Liquid biopsy that discriminates tumor-related biomarkers in body fluids has emerged as an attractive technique for early-stage and accurate diagnosis. Exosomes, carrying membrane and cytosolic information from original tumor cells, impart themselves endogeneity and heterogeneity, which offer extensive and unique advantages in the field of liquid biopsy for cancer differential diagnosis.