Publications by authors named "D J English"
Diverse sources of inhibition serve to modulate circuits and control cell assembly spiking across various timescales. For example, in hippocampus area CA1 the competition between inhibition and excitation organizes spike timing of pyramidal cells (PYR) in network events, including sharp wave-ripples (SPW-R). Specific cellular-synaptic sources of inhibition in SPW-R remain unclear, as there are >20 types of GABAergic interneurons in CA1.
View Article and Find Full Text PDFOrganisms continually tune their perceptual systems to the features they encounter in their environment . We have studied how ongoing experience reorganizes the synaptic connectivity of neurons in the olfactory (piriform) cortex of the mouse. We developed an approach to measure synaptic connectivity , training a deep convolutional network to reliably identify monosynaptic connections from the spike-time cross-correlograms of 4.
View Article and Find Full Text PDFBackground: Higher concentration of insulin-like growth factor-1 (IGF-1) increases postmenopausal breast cancer risk, but evidence for insulin and c-peptide is limited. Further, not all studies have accounted for potential confounding by biomarkers from other biological pathways, and not all were restricted to estrogen receptor (ER)-positive breast cancer.
Methods: This was a case-cohort study of 1,223 postmenopausal women (347 with ER-positive breast cancer) from the Melbourne Collaborative Cohort Study.
Article Synopsis
- Histone Deacetylase 1 (HDAC1) removes acetyl groups from histones, impacting gene expression regulation, but its suppression leads to both increases and decreases in gene activity.
- The study used the dTAG system for rapid HDAC1 degradation in mouse embryonic stem cells, which allowed for specific removal within less than an hour.
- After HDAC1 degradation, most differentially expressed genes were upregulated within two hours, and changes in histone acetylation patterns indicated HDAC1's complex role in managing gene expression and enhancer activity for maintaining pluripotency.
Article Synopsis
- Alcohol consumption is linked to an increased risk of female breast cancer, making it important to understand how cessation impacts this risk.
- A recent meta-analysis found that women who stop drinking may have a reduced risk of estrogen receptor positive (ER+) breast cancer (RR=0.88), while there is no significant risk reduction for estrogen receptor negative (ER-) breast cancer (RR=1.23).
- The study suggests that quitting alcohol may lower the risk of developing ER+ breast cancer, but more research is needed to explore how long cessation effects last.