Validation of the Short Parallel and Extra-Short Form of the Heidelberg Figural Matrices Test (HeiQ).

Figural matrices tests are frequently used to measure fluid intelligence. The HeiQ-an operation-oriented figural matrices test-was developed to tackle limitations of previous matrices tests, mainly the possibility of excluding distractors based on superficial features instead of actively solving the items. However, allowing for a total administration time of 60 min for the assessment of one construct is not feasible in many study designs.

Design and Synthesis of Red-Absorbing Fluoran Leuco Dyes Supported by Computational Screening.

We report here on the design and synthesis of red-absorbing fluoran leuco dyes (LD). An essential part of the present dye development process is a computational screening of the candidate molecules, which allows for both time-efficient and accurate in silico characterization of the dyes. We focus our study here on the robust benzo[a]fluoran scaffold frequently used in leuco dyes.

Construction and Validation of the HeiQ: An Operation-Oriented Figural Matrices Test.

Figural matrices tests are among the most popular and well-investigated tests used to assess inductive reasoning abilities. Solving these tests requires the selection of a target that completes a figural matrix among distractors. Despite their generally good psychometric properties, previous matrices tests have limitations associated with distractor construction that prevent them from realizing their full potential.

Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation.

Integrin-mediated interactions between hematopoietic cells and their microenvironment are important for the development and function of immune cells. Here, the role of the integrin adaptor Kindlin-3 in B cell homeostasis is studied. Comparing the individual steps of B cell development in B cell-specific Kindlin-3 or alpha4 integrin knockout mice, we found in both conditions a phenotype of reduced late immature, mature, and recirculating B cells in the bone marrow.