Publications by authors named "D J DIMAIO"
Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous soft tissue sarcoma and affects an estimated 1,500 people annually in the United States. DFSP frequently exhibits extensive local infiltration. Initial treatment is through surgical excision, and care should be taken to ensure that negative margins are achieved to minimize recurrence.
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- - PDEMA, previously known as CCPDMA, allows for complete histologic visualization of tumor margins, which helps in accurately removing cancerous tissue while preserving healthy tissue.
- - It is the preferred treatment method by NCCN for certain skin cancers due to its high cure rates, with Mohs micrographic surgery being the most common PDEMA technique used in the U.S.
- - The article discusses the differences between Mohs and Tubingen PDEMA techniques, emphasizing the importance of collaboration between surgeons and pathologists, and includes a step-by-step Tubingen protocol with visual aids.
Unlabelled: Rab GTPases control intracellular vesicular transport, including retrograde trafficking of human papillomavirus (HPV) during cell entry, guiding the virus from the endosome to the Golgi network (TGN), the Golgi apparatus, and eventually the nucleus. Rab proteins have been identified that act prior to the arrival of HPV at the TGN, but Rab proteins operating in later stages of entry remain elusive. Here, we report that knockdown of Rab6a impairs HPV entry by preventing HPV exit from the TGN and impeding intra-Golgi transport of the incoming virus.
View Article and Find Full Text PDFThe NCCN Guidelines for Cutaneous Melanoma (termed Melanoma: Cutaneous) provide multidisciplinary recommendations for diagnostic workup, staging, and treatment of patients. These NCCN Guidelines Insights focus on the update to neoadjuvant systemic therapy options and summarize the new clinical data evaluated by the NCCN panel for the recommended therapies in Version 2.2024 of the NCCN Guidelines for Cutaneous Melanoma.
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