Publications by authors named "D J D NICHOLAS"
Around 285 million people worldwide currently have type 2 diabetes and it is projected that this number will be surpassed by 2030. Therefore, it is of the utmost importance to enhance our comprehension of the disease's development. The regulation of diet, obesity, and inflammation in type 2 diabetes is believed to play a crucial role in enhancing insulin sensitivity and reducing the risk of onset diabetes.
View Article and Find Full Text PDFImportance: African Americans have a higher prevalence of Type 2 Diabetes (T2D) compared to White groups. T2D is a health disparity clinically characterized by dysregulation of lipids and chronic inflammation. However, how the relationships among biological and sociological predictors of T2D drive this disparity remains to be addressed.
View Article and Find Full Text PDFLoss of XIST lncRNA unlocks stemness and cellular plasticity in ovarian cancer.
Proc Natl Acad Sci U S A
November 2024
Article Synopsis
- Plasticity in cancer enables tumor cells to switch states, contributing to tumor diversity and challenges in treatment.
- XIST long noncoding RNA is found to be down-regulated in ovarian cancer, correlating with increased cancer stemness and poorer patient outcomes.
- Reducing XIST levels in ovarian cancer cells enhances stemness and alters cell characteristics under specific conditions, highlighting XIST as a potential target for therapies in CSC-rich tumors.
Purpose: Hearing loss (HL) is a leading cause of disability worldwide, but its health-related costs have been incompletely studied. Our objective was to examine the association between HL and direct health care costs and identify subgroups in which costs associated with HL are especially high.
Method: This was a retrospective population-based cohort study of adults treated in a universal health care system between April 2008 and March 2019.
Article Synopsis
- * In addition to its effects on glucose metabolism, insulin affects reproductive health by suppressing the secretion of gonadotropins from the pituitary gland, particularly in states of high insulin levels (hyperinsulinemia).
- * Research using LβT2 gonadotropic cells reveals that insulin stimulation leads to the unexpected movement of GLUT1 transporters to the cell membrane, occurring independently of the typical Akt signaling pathway, suggesting a complex role for insulin in these cells.