Publications by authors named "D J Carey"
Article Synopsis
- Biological aging involves a gradual loss of homeostasis in molecular and cellular functions, particularly in the brain, which contains diverse cell types that differ in their aging resilience.
- This study offers an extensive single-cell RNA sequencing dataset of approximately 1.2 million transcriptomes from brain cells in young and aged mice, identifying 847 cell clusters and 14 age-biased clusters predominantly involving glial types.
- Key findings reveal specific gene expression changes with aging, including decreased neuronal function genes and increased immune-related genes, particularly in cells around the third ventricle of the hypothalamus, suggesting its critical role in the aging process of the mouse brain.
Replicability of Strength Domains in Australian Rules Football Athletes.
J Strength Cond Res
December 2024
Geneau, MC, Carey, DL, Gastin, PB, Robertson, S, and James, LP. Replicability of strength domains in Australian rules football athletes. J Strength Cond Res XX(X): 000-000, 2024-Maximal lower body strength is a multidimensional construct defined as the maximum force application under specific task constraints.
View Article and Find Full Text PDFRecent studies have revealed a role for zinc in insulin secretion and glucose homeostasis. Randomized placebo-controlled zinc supplementation trials have demonstrated improved glycemic traits in patients with type II diabetes (T2D). Moreover, rare loss-of-function variants in the zinc efflux transporter reduce T2D risk.
View Article and Find Full Text PDFPurpose: To identify candidate susceptibility genes for dermatofibrosarcoma protuberans (DFSP).
Methods: All individuals with DFSP from the International Sarcoma Kindred Study ( = 3767 individuals with sarcoma diagnoses from Australia, Europe, New Zealand, and United States) and cohorts that were not ascertained based on sarcoma status or other phenotypes (Geisinger MyCode, = 170,503 individuals, United States; UK Biobank, = 469,789 individuals, United Kingdom) were evaluated for germline pathogenic or likely pathogenic (P/LP) variants in 156 cancer genes.
Results: There were 92 unrelated individuals with DFSP across the 3 cohorts.
The comparative effectiveness of pelvic floor muscle training and hypopressive breathing techniques for pelvic organ prolapse: A systematic review and pooled analysis of randomized controlled trials.
Am J Surg
November 2024
Article Synopsis
- Pelvic floor disorders affect about 25% of women and can lead to conditions like Pelvic Organ Prolapse (POP), which can be treated with PF muscle training (PFMT) and hypopressive breathing (HB).
- A systematic review including seven studies analyzed the effectiveness of PFMT versus HB for improving pelvic health outcomes.
- The results showed PFMT was more effective for increasing pelvic strength, but HB was better at enhancing quality of life, with both techniques showing similar results for muscle contractility.