Differential Associations Between Device-Assessed and Parent-Reported Physical Activity With Indicators of Mental Health in Children and Youth With Disabilities.

Purpose: We examined associations between device-assessed and parent-reported physical activity with mental health indicators among children and youth with disabilities.

Method: Physical activity and mental health data were collected from a larger national surveillance study of physical activity in children and youth with disabilities in Canada. A total of 122 children and youth with disabilities (mean age = 10 y; 80% boys, 57% with developmental disability) wore a Fitbit for 28 days to measure their daily steps.

Morphological studies of labyrinthine tissue in patients affected with Meniere's disease and vestibular schwannoma following labyrinthectomy.

Background: Meniere's disease (MD) is a disabling disease of the inner ear, having a substantial effect on a patient's quality of life. While various postulations regarding its aetiology exists, due to the difficulty with accessing inner ear tissue, there have been limited histological studies in patients with active MD.

Methods: Tissue was collected during labyrinthectomy from 8 patients with intractable MD who had failed medical therapy (22 samples), and 9 patients undergoing translabyrinthine resection of vestibular schwannoma (19 samples).

Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotype.

Proteome changes associated with APOE4 variant carriage that are independent of Alzheimer's disease (AD) pathology and diagnosis are unknown. This study investigated APOE4 proteome changes in people with AD, mild cognitive impairment, and no impairment. Clinical, APOE genotype, and cerebrospinal fluid (CSF) proteome and AD biomarker data was sourced from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database.

Percutaneous Coronary Intervention (PCI) in Patients of Rheumatoid Arthritis(RA): A Systematic Review and Meta-Analysis.

Aim: The present study aims to investigate the outcomes of Percutaneous coronary intervention (PCI) in patients with Rheumatoid arthritis (RA).

Methods: A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to 15 September 2023. All statistical analyses were conducted using Review Manager 5.

Cell salvage for the management of postpartum haemorrhage.

Rationale: Postpartum haemorrhage (PPH), defined as a blood loss of 500 mL or more within 24 hours of birth, is the leading global cause of maternal morbidity and mortality. Allogenic blood transfusions are a critical component of PPH management, yet are often unfeasible, particularly in resource-poor settings where maternal morbidity is highest. Autologous cell salvage in the management of PPH has been proposed to combat limitations in access to allogenic blood and potential transfusion-related risks.