Updates in the Surgical Management of Pancreatic Ductal Adenocarcinoma.

Surgical management of pancreas cancer is complex, including the timing of surgery, surgical approach, intraoperative techniques, and postoperative management, which are reviewed in detail in this manuscript. Ultimately, referral to a high-volume pancreatic surgeon or pancreatic surgery center is critical to ensuring appropriate short-term and long-term outcomes.

Identification of key factors for malnutrition diagnosis in chronic gastrointestinal diseases using machine learning underscores the importance of GLIM criteria as well as additional parameters.

Introduction: Disease-related malnutrition is common but often underdiagnosed in patients with chronic gastrointestinal diseases, such as liver cirrhosis, short bowel and intestinal insufficiency, and chronic pancreatitis. To improve malnutrition diagnosis in these patients, an evaluation of the current Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria, and possibly the implementation of additional criteria, is needed.

Aim: This study aimed to identify previously unknown and potentially specific features of malnutrition in patients with different chronic gastrointestinal diseases and to validate the relevance of the GLIM criteria for clinical practice using machine learning (ML).

Antimicrobial Biomaterials Based on Physical and Physicochemical Action.

Developing effective antimicrobial biomaterials is a relevant and fast-growing field in advanced healthcare materials. Several well-known (e.g.

Adjuvant Therapy Use for Patients With Inadequately Resected T1b-T3 Gallbladder Cancer.

Introduction: Up to 90% of patients undergo inadequate resection for incidentally diagnosed T1b-T3 gallbladder cancer (GBC). We evaluated whether adjuvant therapies (ATs) are associated with prolonged overall survival (OS) for patients undergoing inadequate resection of T1b-T3 GBC.

Methods: Patients who underwent inadequate resection, defined as simple cholecystectomy, for T1b-T3, Nx-N2, and M0 GBC were identified from the National Cancer Database (2004-2016).

Temperature-responsive bioactive glass/polymer hybrids allow for tailoring of ion release.

Intelligent biomaterials react to their surrounding conditions, and hybrid materials are acknowledged for their remarkable customizability, achieved through the meticulous control of nanoscale interactions between organic and inorganic phases. Bioactive glasses (BG) are used clinically to regenerate bone due to their degradability, ion release, and capacity to stimulate the formation of new body tissue. In our study, we developed a core-shell hybrid system using sol-gel derived BG nano particles as the core and poly (-isopropyl acrylamide) (PNIPAM) as the shell.