Publications by authors named "D J Brain"

Objective: Non-alcoholic fatty liver disease (NAFLD) is estimated to affect a third of Australian adults, and its prevalence is predicted to rise, increasing the burden on the healthcare system. The LOCal Assessment and Triage Evaluation of Non-Alcoholic Fatty Liver Disease (LOCATE-NAFLD) trialled a community-based fibrosis assessment service using FibroScan to reduce the time to diagnosis of high-risk NAFLD and improve patient outcomes.

Methods: We conducted a 1:1 parallel randomised trial to compare two alternative models of care for NAFLD diagnosis and assessment.

View Article and Find Full Text PDF

Objectives: Microwave ablation (MWA) has gained attention as a minimally invasive and safe alternative to surgical intervention for patients with small renal masses; however, its cost-effectiveness in Australia remains unclear. This study conducted a cost-effectiveness analysis to evaluate the relative clinical and economic merits of MWA compared to robotic-assisted partial nephrectomy (RA-PN) in the treatment of small renal masses.

Methods: A Markov state-transition model was constructed to simulate the progression of Australian patients with small renal masses treated with MWA versus RA-PN over a 10-year horizon.

View Article and Find Full Text PDF

Background: There is a paucity of high-quality evidence based on clinical endpoints for routine cleaning of shared medical equipment. We assessed the effect of enhanced cleaning and disinfection of shared medical equipment on health-care-associated infections (HAIs) in hospitalised patients.

Methods: We conducted a stepped-wedge, cluster randomised, controlled trial in ten wards of a single hospital located on the central coast of New South Wales, Australia.

View Article and Find Full Text PDF

Purpose: To identify the key attributes of breast cancer follow-up care models preferred by cancer survivors in Australia.

Methods: A discrete choice experiment (DCE) was conducted to elicit preferences for attributes of breast cancer follow-up care. Respondents were presented with two hypothetical scenarios, known as choice sets, and asked to select a preference.

View Article and Find Full Text PDF
Article Synopsis
  • ICU environment affects patient recovery, with issues like noise and poor lighting impacting outcomes and staff wellbeing.
  • The ICU of the Future project aims to improve bedspace design and assess its effects on health metrics through innovative co-designed spaces.
  • This two-year study will involve various assessments (environment, sleep, delirium, etc.) comparing upgraded beds to standard ones to gather data on patient outcomes and the economic impact of improved ICU settings.
View Article and Find Full Text PDF